Who knew Texas had so much to offer? As a native (east) Texan, I never traveled farther west than Lubbock and farther south than Padre Island. I'm not sure why, perhaps I just didn't know anyone who lived in far west Texas. But when my wife and I planned our move (and my return) to Texas, one of the things that excited us the most was our (relatively) close proximity to Big Bend National Park. Our trip took us first to San Antonio where we biked to all of the historic Spanish Missions. Side note, if you care about your body I recommend you avoid the city bikes for such a long ride. On a hot day, they will make a 20 mile bike ride feel like 200! After a couple of days we headed west on HW90 toward the desert.
One thing you need to understand about Big Bend and the surrounding area is that it is remote. Big Bend, Marfa, Marathon, and Alpine are all smack in the middle of the Chihuahuan Desert. All of the plants and animals are perfectly adapted to the harsh environment, but you are not. The better you prepare the happier you will be when you get there. Sun protection and plenty of water should be close-by at all times or else the park can be deadly. Wildlife is everywhere in the park and most are skittish but its best to be aware and never approach wild animals. A long lens is key here, you do not want to be the person walking up to a black bear to get a selfie, it won't end well, pack a telephoto lens and keep your distance. All that being said, prepare to see natural beauty on an unimaginable scale.